GETTING MY PKRRATING TO WORK

The activated enzyme then phosphorylates its main substrate, the translational initiation factor eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to your conserved family of four protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in reaction to different stimuli12, triggering the built-in stress respo